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. 2006 Nov 10;366(1):67–81. doi: 10.1016/j.jmb.2006.11.011

Figure 4.

Figure 4

Inhibitors of PI-3-K reverse the pro-survival effect induced by expression of Tat. CHME5 subline cells harboring pcDNA3.1 (white bars) or pTat101 (gray bars) were pretreated with or without Wortmannin (100 nM) or LY294002 (50 μM) for 30 min. CHX (10 μg/ml) and LPS (10 μg/ml) were added to the cells and incubated for 6 h. Cell viability was then assessed by trypan blue staining (shown as a percentage of cell death). The data represent the mean ± SEM values in three separate sets of experiments.