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. 2012 Jul 3;37(9):381–390. doi: 10.1016/j.tibs.2012.06.001

Figure 2.

Figure 2

Schematic domain architecture of macro-, poly(ADP-ribose)-binding zinc finger (PBZ) and WWE domain containing human proteins. Protein domains illustrated by colored boxes are defined according to the Pfam 26.0 database. (a) Schematic representation of human macrodomain (blue box) containing proteins. Their ability to bind poly(ADP-ribose) (PAR), ADP-ribose (ADPR), or O-acetyl-ADP-ribose (OAADPR), and their hydrolyzing activity toward ADPR-1′′P or OAADPR is indicated, if known. Structural information, when available in the protein data bank (PDB), is indicated. (b) Schematic representation of human PBZ domain containing proteins. Their ability to bind PAR (if known), and the availability of their 3D structures, are indicated. (c) Schematic representation of human WWE domain containing proteins. These WWE-containing proteins are classified according to whether their associated domains are either endowed with poly(ADP-ribose) polymerase (PARP) activity or with ubiquitin E3 ligase activity. Also indicated is whether these WWE domains possess the ability to bind PAR or isoADPR (if known), and whether 3D structural information is available. DDHD, Asp- and His-containing motif involved in phospholipase activity (light gray box); H2A, domain homologous to histone H2A (pale violet box); helicase-C, helicase superfamily C-terminal domain associated with DEXDc-, DEAD- and DEAH-box proteins (lavender box); FHA, forkhead associated (light pink box); HECT, homologous to E6-AP carboxyl terminus domain, displaying E3-ligase activity (light orange box); lactamase B, domain homologous to β-lactamase endowed with nuclease activity (gray box); macro, homologous to the nonhistone part of macroH2A, displaying PAR-binding activity (see text; blue box); PARP, catalytic domain, homologous to the poly(ADP-ribose) synthesis domain of PARP-1, endowed with mono- or poly(ADP-ribosyl)ation activity (green box); PBZ, PAR-binding zinc finger (see text; orange box); RING, really interesting new gene: zinc binding domain with ubiquitin E3 ligase activity (sienna box); SAM-L, sterile α motif-like (purple box); SNF2-N, SNF2 family N-terminal domain (light steel blue box); UBA, ubiquitin-binding domain (silver gray box); WWE, named after its three conserved residues Trp, Trp and Glu, displaying PAR-binding activity (see text; dark yellow box); Zf-CCCH, zinc finger motif (pink box).