Fig. 10.

Inhibition of MEK1/2 with small molecule inhibitors have different effects on TC-83 replication. (A) Toxicity was assessed at 24 h post-treatment by Cell-Titer-Glo assay. (B) U87MG cells were treated with the inhibitors for 2 h and then infected with TC-83 (MOI:0.1) for one hour. Supernatants collected at 24 hpi were subjected to plaque assay.