Table 1.

Anticancer effect of lycorine.

Cancer Type	Cell lines tested	Time (hours)	IC50 (μM)	Anti-tumor ffecet	Ref.
Leukemia	HL-60	24	∼1	Apoptosis, cell cycle arrest	[68]
	U937	48	<5		[77]
	6T-CEM	48	<2		[77]
	K562	48	<2		[78]
Multiple myeloma	U266	48	0.82	HDAC and JAK/STAT signaling inhibition, apoptosis, cell cycle arrest, programmed necrosis, autophagy inhibition	[20]
	KM3	48	1.25		[79]
	RPMI-8226	48	0.70
	ARH-77	24	3.33
	MM.1S	24	4.50
	H929	24	4.10
Prostate cancer	PC-3M	24	2∼5	Inhibition of growth and metastasis	[70]
	DU145
	LNCaP
	22RV1
Human breast cancer	T47D	48	>2	Inhibition of invasion and metastasis	[69]
	MDAMB231	48	∼5		[72]
	MCF-7	72	3.9		[80]
Human bladder cancer	T24	48	7.5	Apoptosis	[71]
Ovarian cancer	Hey1B	24	1.2	Anti-neo vascularization	[65]
	SK-OV-3	72	3.3		[80]
Non-small cell lung cancer	A549	72	6.5		[80]
Large cell lung cancer	NCI-H460	72	3.3		[80]
Colon carcinoma	HCT116	72	3.0		[80]
Human	HepG2,	48	34.1	Apoptosis, repression of Akt signaling and autophagy	[81]
Hepatocellular	SMMC-7721		36.60
Carcinoma	HuH-7		38.34