Fig. 1.

Protein organization and proteolysis. Schematic diagram showing proteolytic processing of the HAstV coat protein. Sites for caspase and trypsin cleavage are indicated with open and filled arrowheads, respectively. Trypsin cleavage of the coat protein between the conserved (white boxes) and variable (shaded boxes) domains is required for viral maturation. The specific pattern of peptide products varies between serotypes. In these experiments, we examined uncleaved particles of HAstV-8 formed by VP70 and fully cleaved particles of HAstV-1.