Table 3.
Nasal and oral shedding of cottontail rabbits (Sylvilagus sp.) experimentally infected with emergent H7N9 (A/Anhui/1/2013) influenza A virus. Values represent log10 PFU/mL.
| Rabbit | Samplea |
Days Post Infection (DPI) |
Serology | |||
|---|---|---|---|---|---|---|
| 1 DPI | 3 DPI | 5 DPI | 7 DPIb | HI titerc | ||
| 1 | Oral | <1 | <1 | <1 | <1 | N/A |
| Nasal | 5.2 | 4.5 | 3.0 | <1.7 | ||
| 2 | Oral | <1 | <1 | 1.0 | <1 | N/A |
| Nasal | 4.0 | 1.7 | 4.0 | <1.7 | ||
| 3 | Oral | 2.0 | <1 | 1.3 | <1 | 80 |
| Nasal | 5.3 | 3.7 | 5.1 | <1.7 | ||
| 4 | Oral | 2.5 | <1 | <1 | <1 | 160 |
| Nasal | 5.8 | 3.6 | 2.6 | 2.3 | ||
| 5 | Oral | <1 | 1 | <1 | <1 | N/A |
| Nasal | 4.1 | 3.9 | <1.7 | <1.7 | ||
| 6 | Oral | <1 | 1.0 | <1 | <1 | 80 |
| Nasal | 4.2 | 2.7 | 2.8 | <1.7 | ||
a
Oral=oral swab; Nasal=nasal flush.
b
Cottontail rabbits 1, 2, and 5 were euthanized on 7 DPI for pathological examination.
c
HI titers were assessed from sera collected at 21 DPI.