Table 4.
Pharmacokinetic parameters of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid in Jin-Yin-Huang extract (n = 6, mean ± SD).
| Parameters | Jin-Yin-Huang |
||||
|---|---|---|---|---|---|
| Chlorogenic acid | Neochlorogenic acid | Cryptochlorogenic acid | 3,5-Dicaffeoylquinic acid | 3,4-Dicaffeoylquinic acid | |
| Cmax (ng ml−1) | 242 ± 69a | 151 ± 38Δ,a | 137 ± 57Δ | 81 ± 36Δ | 74 ± 43Δ |
| Tmax (min) | 30.0 ± 0.00 | 30.0 ± 0.00 | 30.0 ± 0.00 | 31.7 ± 17.7 | 53 ± 14 |
| AUC0–t (ng min ml−1) | 80,579 ± 14,910a | 45,140 ± 13,091Δ | 42,809 ± 12378Δ | 43,355 ± 9408Δ | 37177 ± 9426Δ |
| AUC0–∞ (ng min ml−1) | 93,054 ± 15,266a | 49,269 ± 11,554Δ | 48,022 ± 12,765Δ | 51,271 ± 5382Δ | 51,145 ± 8921Δ |
| MRT0–t (min) | 440 ± 24a | 395 ± 35a | 418 ± 26a | 466 ± 73a | 542 ± 61Δ |
| T1/2z (min) | 513 ± 29a | 428 ± 165.a | 450 ± 41a | 378 ± 69.6a | 652 ± 37Δ |
a
p < 0.05 vs (3,4-dicaffeoylquinic acid), (Δ) p < 0.05 vs (chlorogenic acid).