Table 5.
Pharmacokinetic parameters of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid in Qing-Re-Jie-Du extract (n = 6, mean ± SD).
| Parameters | Qing-Re-Jie-Du extract |
||||
|---|---|---|---|---|---|
| Chlorogenic acid | Neochlorogenic acid | Cryptochlorogenic acid | 3,5-Dicaffeoylquinic acid | 3,4-Dicaffeoylquinic acid | |
| Cmax (ng ml−1) | 320 ± 144a | 227 ± 96a | 154 ± 50.3Δ | 121 ± 42Δ | 55.5 ± 18.3Δ |
| Tmax (min) | 35.0 ± 7.1 | 30.0 ± 0.0 | 30.0 ± 0.0 | 30.0 ± 14.1 | 30.0 ± 0.0 |
| AUC0–t (ng min ml−1) | 58,878 ± 7687a | 32,149 ± 4772a,Δ | 28,688 ± 3546Δ | 25,205 ± 8934Δ | 20,357 ± 2819Δ |
| AUC0–∞(ng min ml−1) | 71,733 ± 22,160a | 36,078 ± 8844Δ | 34,217 ± 8607Δ | 44,537 ± 29,583Δ | 37,807 ± 15,904Δ |
| MRT0–t (min) | 418 ± 64a | 334 ± 121a | 386 ± 88a | 474 ± 80Δ,a | 624 ± 52Δ |
| T1/2z (min) | 386 ± 173a | 361 ± 69a | 463 ± 210 | 550 ± 244 | 606 ± 67Δ |
a
p < 0.05 vs (3, 4-dicaffeoylquinic acid), (Δ) p < 0.05 vs (chlorogenic acid).