. 2013 Aug 17;86:189–197. doi: 10.1016/j.jpba.2013.08.010

Table 7.

Pharmacokinetic parameters of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid in Shuang-Huang-Lian extract (n = 6, mean ± SD).

Parameters	Shuang-Huang-Lian
	Chlorogenic acid	Neochlorogenic acid	Cryptochlorogenic acid	3,5-Dicaffeoylquinic acid	3,4-Dicaffeoylquinic acid
C_max (ng ml⁻¹)	264 ± 107^a	215 ± 52^a	120.3 ± 41.4^Δ	70.1 ± 14.4^Δ	73.5 ± 27.8^Δ
T_max (min)	60.0 ± 11.6	65.0 ± 10.0	65.0 ± 5.8	60.0 ± 14.1	65.0 ± 5.8
AUC_0–t (ng min ml⁻¹)	61,570 ± 13,937	45,504 ± 16,518	35,023 ± 8861^Δ	32,821 ± 8933^Δ	38,004 ± 5612
AUC_0–∞(ng min ml⁻¹)	87,646 ± 38,356	81,997 ± 31,025	44,759 ± 12,888	52,813 ± 27,821	88,148 ± 10,111
MRT_0–t (min)	463 ± 49^a	450 ± 146^a	485 ± 61^a	566 ± 60	641 ± 54^Δ
T_1/2z (min)	295 ± 65^a	316 ± 135^a	566 ± 224	503 ± 87^Δ	673 ± 74^Δ

^ap < 0.05 vs (3,4-dicaffeoylquinic acid), (Δ) p < 0.05 vs (chlorogenic acid).