Table 2.
Cytotoxicity in diverse mammalian cell lines.
| Compound | Cytotoxicity |
|||||
|---|---|---|---|---|---|---|
| MCC (μM)a |
CC50 (μM)b |
|||||
| Vero | HeLa | MDCK | HEL | CRFK | MT-4 | |
| 4a | >100 | >100 | >100 | >100 | >100 | >125 |
| 4b | >100 | >100 | >100 | >100 | >100 | 96 |
| 4c | >100 | >100 | >100 | >100 | >100 | 76 |
| 4d | >100 | >100 | >100 | >100 | >100 | 64 |
| 4e | >100 | >100 | >100 | >100 | >100 | >125 |
| 4f | >100 | >100 | >100 | >100 | >100 | >125 |
| 4g | 100 | >100 | >100 | >100 | >100 | >125 |
| 4h | 100 | ⩾100 | >100 | >100 | >100 | >125 |
| 4i | >100 | >100 | >100 | >100 | >100 | >125 |
| 4j | >100 | >100 | >100 | >100 | >100 | >125 |
| 4k | >100 | >100 | >100 | >100 | >100 | >125 |
| 4l | >100 | >100 | >100 | >100 | >100 | >125 |
| 4m | ⩾100 | >100 | >100 | 100 | >100 | 50 |
| 5 | >100 | >100 | >100 | >100 | >100 | >125 |
The following cell lines were used: Vero, African green monkey kidney cells; HeLa, cervix carcinoma cells; MDCK, Madin-Darby canine kidney cells; HEL, human embryonic lung fibroblast cells; CRFK, Crandell-Rees feline kidney cells; MT-4, human T-lymphoblast cells.
a
MCC: minimal cytotoxic concentration, or compound concentration producing minimal alterations in cell morphology, as detected by microscopical inspection.
b
CC50: 50% cytotoxic concentration, determined by the colorimetric and formazan-based MTS cell viability test.