Table 3.

Microsomal Stability and Predicted Plasma Clearance of CLBQ14

Species	Percent Remaininga (%)	Clpredictedb (L/h/kg)	Clpredictedb (mL/min/kg)	Hepatic Blood Flowc (mL/min/kg)
CD-1 Mouse	3.7 ± 1.36	3.2 ± 0.17	52.9 ± 3.56	90
SD Rat	26.8 ± 2.37	1.9 ± 0.17	31.4 ± 3.41	55
Cynomolgus monkey	17.5 ± 0.86	1.7 ± 0.02	28.2 ± 0.31	44
Human	35.5 ± 0.33	0.8 ± 0.12	13.9 ± 2.40	21

Notes: ^aPercent remaining after incubation in liver microsomes for 1 hr. ^bPredicted hepatic clearance by well-stirred model. ^cHepatic blood flow obtained from literature.³⁰