Table 4.
CLBQ14 Pharmacokinetic Parameters Generated by Non-Compartmental Analysis
| Pharmacokinetic Parameters (Units) | Mean Estimate ± SD | Description of Pharmacokinetic Parameters | ||
|---|---|---|---|---|
| IV (2mg/kg) | PO (20 mg/kg) | SC (10 mg/kg) | ||
| C0/Cmax (mg/L) | 2.4 ± 0.66 | 1.7 ± 0.65 | 0.9 ± 0.11 | C0/Cmax = initial/maximum plasma concentration; |
| Tmax (h) | – | 0.5 ± 0.00 | 1.2 ± 0.66 | Tmax = time taken to reach maximum plasma concentration; |
| AUC0-∞ (mg/L/hr) | 1.2 ± 0.06 | 4.5 ± 1.77 | 5.3 ± 0.50 | AUC0-∞ = area under curve from time zero to infinity; |
| AUC0-∞/D (h*kg*mg/L/mg) | 0.6 ± 0.03 | 0.2 ± 0.09 | 0.5 ± 0.05 | AUC0-∞/D = dose normalized area under curve; |
| Cl (L/kg/hr) | 1.67 ± 0.08 | – | – | Cl = total body clearance; |
| Cl/F (L/kg/hr) | – | 5.1 ± 2.54 | 1.9 ± 0.18 | Cl/F = total body clearance for extravascular route; |
| VD (L/kg) | 21.3 ± 0.57 | – | – | VD = volume of distribution of central compartment; |
| VD/F (L/kg) | – | 39.9 ± 16.3 | 15.1 ± 2.40 | VD/F = volume of distribution for extravascular route; |
| T1/2 (hr) | 8.9 ± 0.22 | 5.6 ± 0.62 | 5.6 ± 0.32 | T1/2 = elimination half-lives; |
| MRT (hr) | 12.5 ± 0.61 | 6.8 ± 0.95 | 7.8 ± 0.61 | MRT = mean residence time; |
| Fabs (%) | – | 39.4 ± 12.6 | 90.0 ± 7.20 | Fabs = absolute bioavailability. |