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. 2020 Apr 3;4(2):026102. doi: 10.1063/1.5142728

FIG. 6.

FIG. 6.

Representative in situ ultrasound [(a)–(c)], 1100 nm PAT [(d)–(f)], and 1210 nm PAT [(g)–(i)] images of LCA at days 7, 10, and 14 post-PCL. Regional assessment of lipid specific PAT SNR (j) and PAT lipid volume (k) suggested statistically significant and rapid lipid accumulation between days 7 and 14, with greater lipid accumulation in the caudal most regions at day 14. Comparison of the lipid volume and lumen volume/length suggests compensatory remodeling of the LCA until day 10, potentially due to Glagov remodeling, followed by a rapid decrease in the lumen volume and increase in lipid volume (l). Regional assessment of hemoglobin specific PAT SNR (m) and PAT hemoglobin volume (n) revealed the presence of intraplaque hemorrhages at day 10 with a 98.9% increase blood volume between days 10 and 14. Statistical significance determined at p < 0.05 (* = significance between groups, † = significance compared to the same day in region 1, # = significance compared to day 4 in the same region, & = significance compared to day 7 in the same region, ⊗ = significance compared to sham group, ⊕ = significance compared to right contralateral control RCA). Scale bar: 1 mm.