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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Cancer Res. 2020 Feb 3;80(7):1428–1437. doi: 10.1158/0008-5472.CAN-19-1394

Figure 5. IRS2 expression promotes cell migration in a PI3K dependent manner but is not sufficient for tumorigenesis.

Figure 5.

A) Overexpression of IRS2 in Rosa26-ERG organoids is not associated with increased cell proliferation. Experiment performed in triplicate with error bars reporting standard deviation from the mean. B) Overexpression of IRS2 promotes cell migration in a Boyden chamber assay. Experiment performed in triplicate with measuring cell density with error bars reporting standard deviation from the mean. C) Western blot comparison of IRS2 overexpression compared to shPten demonstrates a greater increase in pAkt signaling following knock-down of Pten (experiment run in triplicate). D) Model of the selective evolution of prostate cancer progression in tumor harboring ERG genomic rearrangements. E) Genomic data from TCGA profiled primary prostate cancers demonstrate a significant enrichment for PTEN loss in ERG positive prostate cancers. F) RPPA data from TCGA profiled primary prostate cancers demonstrated a significant reduction in protein expression of INPP4B and PTEN in ERG positive tumors.