Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of the signaling pathways activated by receptor tyrosine kinases and activating a Ras family GTPase. Note that some RTKs can activate both Ras and Rap.
| RTK | EGFR | TrkA/B |
| Growth factor | EGF | NGF, BDNF |
| Adaptor | Shc, Grb2 | Cbl, Crk |
| GEF | Sos | C3G |
| GTPase | Ras | Rap |
