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Schematic representation of cardiomyocyte action potential (AP) responses to stretch-activated ion channel (SAC) opening at different timings during the AP. Within a short critical time-window during early ventricular repolarization (just prior to the peak of the T wave; see schematic ECG trace), these can combine to render both trigger (red) and sustaining mechanisms (blue) for ventricular rhythm disturbances (Commotio cordis). Reproduced from (Kohl et al., 2001).
