Figure 5:

Mechanically-induced arrhythmia in the regionally-ischemic rabbit heart. A. Distribution of muscle strain (E_ff) in the normal and ischemic heart during systole. B. Evolution of a mechanically-induced ventricular premature beats (VPB). C. Vm traces at sites 1 and 2 marked in the 191-ms inset in B. Black arrow and dashed circle denote mechanically-induced depolarization at these sites. Red arrow indicates activation at site 2 by propagation of the mechanically-induced VPB. D. Activation maps for the full model, model No_SAC, and model No_Ischemia during VPB. No_SAC incorporates all the electrophysiological changes in ischemia, but without involvement of SAC, and, thus, without mechanically-induced DADs; external stimuli were applied at the same time and locations where the mechanically-induced VPB originated in the full model (arrows in 191-ms inset in B). No_Ischemia included SAC and thus the spatial distribution of mechanically-induced DADs, but without ischemia-induced electrophysiological changes. Black lines denote conduction block. Asterisk: reentry exit site. Snapshots of transmembrane potentials are also presented for models No_SAC and No_Ischemia. Modified from (Jie et al., 2010).