Table 3.
Multivariate logistic regression analyses of three SNPs in PPARG gene with the risk of OSA in all subjects
| SNPs | Genotype | unadjusted | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|---|
| OR (95CI) | Pa | OR (95CI) | Pa | OR (95CI) | Pa | ||
| rs1801282 | CC (N = 285) | 1 | 1 | 1 | |||
| CG (N = 41) | 0.406 (0.208–0.792) | 0.040* | 0.278 (0.126–0.612) | 0.005* | 0.318 (0.136–0.746) | 0.008* | |
| rs3856806 | CC (N = 198) | 1 | 1 | 1 | |||
| CT (N = 118) | 0.730 (0.443–1.205) | 0.657 | 1.393 (0.731–2.654) | 0.626 | 0.898 (0.479–1.683) | 0.898 | |
| TT (N = 10) | 0.520 (0.141–1.918) | 0.326 | 0.635 (0.234–1.726) | 0.373 | 0.684 (0.125–3.737) | 0.684 | |
| rs13073869 | GG (N = 137) | 1 | 1 | 1 | |||
| GA (N = 152) | 1.376 (0.816–2.322) | 0.462 | 1.378 (0.752–2.523) | 0.897 | 1.643 (0.856–3.153) | 0.136 | |
| AA (N = 37) | 0.561 (0.266–1.182) | 0.512 | 0.552 (0.230–1.324) | 0.732 | 0.654 (0.258–1.657) | 0.371 | |
Model 1: adjusted for age, sex, BMI, smoker and drinker. Model 2: adjusted for model 1 + TG, HDL-C, FBG and ESS
SNPs single nucleotide polymorphisms, PPARG peroxisome proliferator-activated receptor gamma, OSA obstructive sleep apnea, BMI body mass index, TG triglycerides, HDL-C high-density lipoprotein cholesterol, FPG fasting plasma glucose, ESS Epworth Sleepiness Scale, PaP value was adjusted by step-down Bonferroni
*P < 0.05