Table 3.
Hazard ratios (95% confidence interval) for all-cause mortality, cardiovascular mortality, and non-cardiovascular mortality in each OSA severity category when the severity classification was based on full-night AHI (AHIstandard), and the 2 h with highest AHIs (AHI2h)
| OSA severity: mild | OSA severity: moderate | OSA severity: severe | Age (increase of 1 year) | BMI (increase of 1 unit) | Male gender | Smoking: yes | Smoking: quit | CPAP | |
|---|---|---|---|---|---|---|---|---|---|
| All-cause mortality | |||||||||
| AHIstandard | 1.13 (0.84–1.51) | 1.76* (1.27–2.44) | 1.75* (1.22–2.51) | 1.09* (1.08–1.10) | 1.04* (1.02–1.05) | 1.55* (1.15–2.08) | 2.37* (1.82–3.09) | 1.13 (0.86–1.49) | 0.73* (0.55–0.96) |
| AHI2h | 1.33 (0.93–1.91) | 1.56* (1.07–2.27) | 1.94* (1.33–2.83) | 1.09* (1.07–1.10) | 1.04* (1.02–1.05) | 1.53* (1.14–2.06) | 2.37* (1.82–3.09) | 1.13 (0.86–1.48) | 0.75* (0.57–0.98) |
| Cardiovascular mortality | |||||||||
| AHIstandard | 0.90 (0.57–1.44) | 1.61 (0.98–2.63) | 1.44 (0.83–2.51) | 1.13* (1.10–1.15) | 1.05* (1.03–1.08) | 2.26* (1.38–3.70) | 3.47* (2.29–5.23) | 1.22 (0.79–1.88) | 0.71 (0.46–1.09) |
| AHI2h | 1.09 (0.62–1.92) | 1.28 (0.71–2.30) | 1.64 (0.92–2.90) | 1.13* (1.11–1.15) | 1.05* (1.03–1.08) | 2.23* (1.36–3.65) | 3.44* (2.28–5.19) | 1.21 (0.79–1.87) | 0.71 (0.47–1.08) |
| Non-cardiovascular mortality | |||||||||
| AHIstandard | 1.28 (0.88–1.87) | 1.99* (1.28–3.11) | 2.32* (1.46–3.70) | 1.08* (1.06–1.10) | 1.02* (1.00–1.05) | 1.26 (0.86–1.82) | 2.02* (1.43–2.84) | 1.09 (0.77–1.54) | 0.66* (0.46–0.96) |
| AHI2h | 1.53 (0.96–2.45) | 1.84* (1.13–3.01) | 2.46* (1.49–4.07) | 1.08* (1.06–1.10) | 1.03* (1.00–1.05) | 1.25 (0.86–1.81) | 2.03* (1.43–2.86) | 1.09 (0.77–1.54) | 0.71 (0.49–1.02) |
Hazard ratios were calculated with Cox proportional hazards model. Statistically significant (p < 0.05) hazard ratios are denoted with an asterisk (*)