Table 3.

List of nonneuropathic localised amyloidosis type diseases

Protein or peptide	Associated disease	Native structure
Amylin or Islet amyloid polypeptide (IAPP)	Type II diabetes	Native structure unfolded
Calcitonin	Medullary carcinoma of the thyroid	Native structure unfolded
ANF	Atrial amyloidosis	Native structure unfolded
Amyloid β peptide mutants	Hereditary cerebral haemorrhage and amyloidosis	Native structure unfolded
Prolactin	Pituitary prolactinoma	α helical and 4-helical cytokines
Insulin, Enfuviritide	Injection localised amyloidosis	α helical and insulin-like
Keratin	Cutaneous lichen amyloidosis	Not known
Amyloid β peptide	Inclusion body myositis	Native structure unfolded
Lung surfactant protein C	Pulmonary alveolar proteinosis	Not known
γ- crystallin	Cataract	β sheets like γ crystallin
Corneodesmosin	Hypotrichosis simplex of the scalp	Native structure unfolded
Lactotransferrin	Corneal dystrophy gelatinous like	α + β both, periplasmic binding protein II

All of the nonneuropathic localised diseases mentioned above are sporadic although hereditary forms have also been reported except hereditary cerebellar haemorrhage and pulmonary alveolar proteinosis which are predominantly genetic although sporadic forms have also been reported (Chiti and Dobson 2017)