Table 2.
Biochemical parameters measured during the course of study.
| Parameter | Units | Ref range | Week 0 | Week 4 | Week 12 | Week 24 |
|---|---|---|---|---|---|---|
| Average value ± SEM | ||||||
| Blood glucose | mg/ml | 90–120 | 121.4 ± 5.12 | 113.66 ± 2.41 | 113.26 ± 3.16 | 111.72 ± 3.70 |
| Albumin | g/dl | 3.2–4.8 | 4.36 ± 0.046 | 4.37 ± 0.054 | 4.31 ± 0.061 | 4.35 ± 0.046 |
| Alkaline phosphatase | U/l | 42–98 | 90.33 ± 3.70 | 85.59 ± 3.37 | 85.50 ± 3.34 | 90.60 ± 3.93 |
| ALT | U/l | 10–28 | 16.52 ± 0.96 | 17.11 ± 1.42 | 17.2 ± 1.48 | 21.11 ± 3.2 |
| AST | U/l | <31 | 22.02 ± 1.07 | 22.54 ± 1.37 | 22.43 ± 1.27 | 27.11 ± 2.44 |
| Bilirubin (direct) | mg/dl | <0.3 | 0.17 ± 0.015 | 0.16 ± 0.012 | 0.17 ± 0.016 | 0.18 ± 0.013 |
| Bilirubin (indirect) | mg/dl | 0–0.9 | 0.39 ± 0.023 | 0.37 ± 0.025 | 0.41 ± 0.033 | 0.43 ± 0.033 |
| Blood urea nitrogen | mg/dl | 7–25 | 9.06 ± 0.58 | 10.47 ± 0.52 | 10.51 ± 0.62 | 11.71 ± 0.65 |
| Glomerular filtration rate | ml/min/1.73 m2 | ≥90 | 120.17 ± 1.75 | 122.66 ± 2.12 | 122.06 ± 2.80 | 123.13 ± 2.09 |
| Serum calcium | mg/dl | 8.8–10.6 | 9.24 ± 0.077 | 9.35 ± 0.11 | 9.23 ± 0.12 | 9.51 ± 0.064 |
| Serum creatinine | mg/dl | 0.5–0.8 | 0.65 ± 0.014 | 0.63 ± 0.016 | 0.64 ± 0.024 | 0.62 ± 0.015 |
| HOMA index value | — | 0.7–2 | 1.44 ± 0.15 | — | — | 1.88 ± 0.19 |