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. 2020 Mar 24;2020:7079308. doi: 10.1155/2020/7079308

Figure 6.

Figure 6

Meloxicam arrests tumor growth in vivo. (a–d) Nude mice bearing established Huh-7 and Hep3B tumors were treated with 0.9% NS or meloxicam (30 mg/kg) for 35 . (a) Tumors from mice after tumor implantation are shown. The average tumor volume for each group was calculated. ∗∗P < 0.01. (b) Representative images of tumor sections stained with antibodies against HIF-1α, Ki-67, CD31, and the TUNEL agent (magnification × 200). (c) Expression and distribution of VEGFA in xenograft tumor tissues were determined by immunofluorescent photomicrography (magnification, ×200). (d) Western blot analysis of Huh-7 and Hep3B cell-derived tumors treated with 0.9% NS or meloxicam (30 mg/kg) for expressions of HIF-1α, VEGFA, and pVHL. GAPDH was measured as the loading control.