TABLE III.
Comparison of lung transplant recipients with influenza to those without
| Patients with influenza (n = 9) | Patients without influenza (n = 9) | |
|---|---|---|
| Mean age (years) | 42.3 | 42.7 |
| Gender M:F | 6:3 | 5:4 |
| Transplant type | 6 BSLT, 2 SLT, 1 HLT | 6 BSLT, 2 SLT, 1 HLT |
| Acute rejection episodes∗ | 1.22 | 1.33 |
| POD† | 988 ± 535 (134–1795) | 1,488 ± 902 (44–2890) |
| FEV1 decline† | ||
| (1) Volume | 418 ± 377 ml (0–1330) | 176 ± 187 ml (0–585) |
| (2) Percentage | 23 ± 13 (0–44) | 15 ± 14 (0–33) |
| LRT symptoms | 8/9 | 4/9 |
| Clinical signs | ||
| Hypoxia‡ | 4/9 | 2/9 |
| Leukocytosis§ | 1/9 | 0/9 |
| Fever∥ | 8/9 | 2/9 |
| Radiographic changes | 5/9 | 0/9 |
| Influenza vaccine | 8/9 | 9/9 |
| Bronchoscopy | 3/9 | 0/9 |
| Number hospitalized | 8/9 | 3/9 |
| Treatment | ||
| Steroids (p.o. or IV) | 7/9 | 2/9 |
| IV antibiotics | 7/9 | 4/9¶ |
BSLT, bilateral sequential single-lung transplant; SLT, single-lung transplant; HLT, heart–lung transplant; POD, post-operative day; LRT, lower respiratory tract; p.o., per oral; IV, intravenous.
∗
Average number per patient post-transplant.
†
Values expressed as mean ± standard deviation (range).
‡
Resting oxygen saturation <92.
§
White cell count >11,000 mm3.
∥
Temperature ≥37.6°C.
¶
Anti-microbial therapy included ambisome for 2 cases of Aspergillus infection.