Figure 1.

The number of surgical biopsies performed on postallogeneic HCT recipients in 3 eras, 1993 to 1997, 2003 to 2007, and 2013 to 2015, broken into diagnostic categories. *Includes 4 cases that were Aspergillus and CMV combined diagnosis. Each counted individually in subgroups leading to a total 58 versus total number of biopsies, 54. †Adjusted hazard ratio for surgical lung biopsy between early and late cohort. Adjusted for patient age, severity of disease (low, intermediate, high), and donor type. ‡Comparison of proportion of aspergillosis cases between early and late cohorts.