Table I. Gene ontology analysis of ISG15-induced differential gene expression in skin.
| Pathway Name | No. Entities Found | No. Entities Total | p Value | False Discovery Rate |
|---|---|---|---|---|
| Collagen degradation | 15 | 57 | 6.35 × 10−13 | 1.13 × 10−10 |
| Extracellular matrix organization | 29 | 295 | 6.87 × 10−13 | 1.13 × 10−10 |
| Assembly of collagen fibrils and other multimeric structures | 14 | 61 | 2.28 × 10−11 | 2.49 × 10−9 |
| Degradation of extracellular matrix | 18 | 135 | 1.97 × 10−10 | 1.62 × 10−8 |
| Collagen formation | 15 | 88 | 2.57 × 10−10 | 1.67 × 10−8 |
| Collagen biosynthesis and modifying enzymes | 11 | 64 | 6.17 × 10−8 | 3.33 × 10−6 |
| Extracellular matrix proteoglycans | 10 | 51 | 7.50 × 10−8 | 3.53 × 10−6 |
| Collagen chain trimerization | 9 | 41 | 1.34 × 10−13 | 5.48 × 10−6 |
| Integrin cell surface interactions | 11 | 81 | 6.22 × 10−7 | 2.24 × 10−5 |
| NCAM1 interactions | 6 | 22 | 5.13 × 10−6 | 1.64 × 10−4 |
| Activation of matrix metalloproteases | 7 | 51 | 6.72 × 10−5 | 0.00195 |
| Axon guidance | 16 | 272 | 8.23 × 10−5 | 0.00222 |
| Signaling by PDGF | 7 | 57 | 1.33 × 10−4 | 0.00321 |
| NCAM signaling for neurite outgrowth | 6 | 40 | 1.39 × 10−4 | 0.00321 |
| Other semaphorin interactions | 4 | 14 | 1.71 × 10−4 | 0.00359 |
Pathway analysis using Reactome overrepresentation analysis of the 254 overexpressed genes (log fold change > 0 out of the total of 444 differentially expressed genes in Fig. 1B). The top 15 pathways are depicted.