Table 2.

Mediators involved in regulation of CD163 receptor.

Mediator	Upregulation	Downregulation	References
IL-6	+	−	Buechler et al. (2000)
IL-10	+	−	Buechler et al. (2000)
			Sulahian et al. (2000)
			Weaver et al. 2007
			Patton et al. (2009)
M-CSF	+	−	Ritter et al. (1999)
Hb–Hp complexes	+	−	Ugocsai et al. (2006)
Dexamethasone	+	−	Ritter et al. (1999)
TNF-α	−	+	Buechler et al. (2000)
IFN-γ	−	+	Buechler et al. (2000)
			Weaver et al. (2007)
TGF-β	−	+	Pioli et al. (2004)
GM-CSF+IL-4	−	+	Ritter et al. (1999)
Lipopolysaccharide	−	+	Buechler et al. (2000)
			Patton et al. (2009)
12-O-tetradecanoylphorbol-13-acetate	−	+	Patton et al. (2009)

IL, interleukin; M-CSF, macrophage colony-stimulating factor; HB–Hp, haemoglobin–haptoglobin; TNF, tumour necrosis factor; IFN, interferon; TGF, transforming growth factor; GM-CSF, granulocyte macrophage colony-stimulating factor.