Figure 3.

Requirement and Regulation of TLR7-MyD88-IRF7 in Type I IFN-Mediated Protection of Mice from YM Infection

(A) Serum amounts of IFN-α/β in WT, Myd88^−/−, Mavs^−/−, and Mavs^−/−:Myd88^−/− mice at 0, 18, and 24 hr after YM infection.

(B) Daily YM parasitemias and mortality rates of WT, Myd88^−/−, Mavs^−/−, and Mavs^−/−:Myd88^−/− mice after YM infection.

(C) Serum amounts of IFN-α/β in WT, Tlr7^−/−, Tmem173^gt, and Tmem173^gt:Tlr7^−/− mice at 0, 24, and 48 hr after YM infection.

(D) Serum amounts of IFN-α/β in WT and indicated deficient mice at 24 hr after YM infection.

(E–F) Daily YM parasitemias and mortality rates of WT and indicated deficient mice after YM infection.

Data are plotted as the mean ± SD and are representative of three independent experiments. ^∗∗p < 0.01, ^∗∗∗p < 0.001 versus corresponding control. ND, not detected.

See also Figure S3.