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The impact of vaccines on disease burden in the USA
| Disease | Maximum number of cases identified (year) | Cases reported in 2001 | Reduction in disease(%) |
| Smallpox | 48,164 (1901) | 0 | 100.00 |
| Diphtheria | 206,939 (1921) | 2 | 99.99 |
| Pertussis | 265,269 (1934) | 4788 | 98.20 |
| Tetanus | 1560 (1923) | 26 | 98.34 |
| Polio | 21,269 (1952) | 0 | 100.00 |
| Measles | 894,134 (1941) | 96 | 99.99 |
| Rubella | 57,686 (1969) | 19 | 99.97 |
| Mumps | 152,209 (1968) | 216 | 99.86 |
| Hemophilus influenzae | 20,000 (1992) | 51 | 99.75 |
Adapted from Ref. [48].
