Table 3.

Treatments and outcomes in 16 ferrets with cryptococcosis

	Treatment	Route, Dose, Interval	Duration	Outcome	Ref.
1.	None			Presented deceased	6
2.	None			Presented deceased	8
3.	None			<3 mo died of lymphosarcoma	16
4.	Dexamethasone SP	0.15–0.5 mg/kg q 8–48 h	Tapered over 30 d	4 wk PT: improved CS 5 wk PT: euthanized because of cardiac disease; post mortem indicated CNS cryptococcosis	9
5.	Surgical debulking			171 d PT: nasal disease resolved 3 y PT: euthanized because of abdominal mass; post mortem showed no signs of cryptococcosis	7, 12
	Itraconazole	25 mg PO every 24 h	21 d
		33 mg PO every 24 h	21–171 d
		25 mg PO every 24 h	171 d to 3 y
6.	Itraconazole	33 mg PO every 24 h	Unknown	Initial improvement Euthanized Post mortem: cryptococcus in enlarged and contralateral LN	7
7.	None			Died after sedation	7
8.	None			Died during induction	7
9.	Itraconazole	25 mg/kg PO every 24 h	6 mo	5 wk PT improved 6 mo PT antigen titer 0	7
10.	Surgical excision affected digit			4 mo PT no disease recurrence	7
11.	Fluconazole	12 mg PO every 12 h	≥4 mo	4 mo PT doing well but dragging limb	7
12.	None			Not reported	15
13.	None			Not reported	15
14.	Itraconazole	15 mg/kg PO every 24 h	43 wk	3 wk PT decreased size of LN, stopped regurgitating 6 wk PT normal sized LN 40 wk PT antigen titer 0	10
15.	Itraconazole	10 mg/kg PO every 12 h	4 d	Died 4 d PT Post mortem showed disseminated cryptococcosis	11
	Amphotericin B	0.25 mg/kg IV every 24 h	4 d
16.	Fluconazole	10 mg/kg PO every 24 h	6 mo	4 mo PT clinical signs improved but antigen titer unchanged 7 mo PT euthanized because of CNS signs Post mortem showed disseminated cryptococcosis	13, 14
	Prednisone	0.5 mg/kg PO every 24 h	6 mo
	Diclofenac	OU every 4–8 h	5.5 mo

Abbreviations: CNS, central nervous system; CS, clinical signs; IV, intravenously; LN, lymph nodes; OU, in both eyes; PO, by mouth; PT, post treatment.