Table 3.

The parameters used in the p53-MDM2 feedback regulatory loop.

Parameters	Description	Constant
SP53	Basal induction rate of p53 mRNA	0.01
Smdm2	Basal induction rate of MDM2 mRNA	0.002
krp	Translation rate of p53 mRNA	0.12
$k_{p^{\ast }p}$	Dephosphorylation rate of p53∗	0.2
$k_{{\text{app}}^{\ast }}$	ATM∗-dependent phosphorylation rate of p53	0.6
kmp	Mdm2-dependent degradation rate of p53	0.1
$006B_{p^{\ast }m}$	p53-dependent Mdm2 transcription rate	0.03
$k_{{\text{mp}}^{\ast }}$	Mdm2-dependent degradation rate of p53∗	0.02
kmat	ATM∗-dependent degradation rate of Mdm2	0.01
kmrp	Translation rate of Mdm2 mRNA	0.02
drp	Degradation rate of p53 mRNA	0.02
dpp	Basal degradation rate of p53	0.02
$d_{{\text{pp}}^{\ast }}$	Basal degradation rate of p53∗	0.008
dmr	Degradation rate of Mdm2 mRNA	0.01
dmp	Basal degradation rate of Mdm2	0.003
kp	Michaelis constant of ATM-dependent p53 phosphorylation	1.0
k	Michaelis constant of p53-dependent Mdm2 transcription	1.0
kd	Threshold for Mdm2-dependent p53 degradation	0.03
n	Hill coefficient of the Mdm2 transcription rate	4
kat	Threshold of ATM-dependent Mdm2 degradation	1.60
$k_{{\text{d}}^{\ast }}$	Threshold of Mdm2-dependent p53∗ degradation	0.32