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. 2007 Apr 2;18(4):159–166. doi: 10.1016/j.tem.2007.03.003

Figure 4.

Figure 4

In the lung, ACE converts angiotensin I (ANG I) into ANG II, which acts as a vasopressor and a mitogen for smooth muscle cells and fibroblasts through the angiotensin 1 (AT1) receptor. By contrast, ACE2 [53] converts ANG I and ANG II into angiotensin (1–9) and angiotensin (1–7), respectively, which cause vasodilatation and apoptosis through the AT2 receptor 3, 51.