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Schematic representations of MHV S protein and the construct used in this study. SS, signal sequence; TM, transmembrane domain; HR1 and HR2, heptad repeats 1 and 2. Cleavage site of S1 and S2 domains is shown. Amino acid sequences of the HR1 and HR2 regions are shown and the 2-helix construct is schematically represented.
