Reference	Objective	Design	Evidence
Aspromonte et al. [220]	To evaluate whether BNP measurement associated with echocardiography could effectively stratify patients with new symptoms	CSS	4A+
Mikkelsen et al. [221]	To assess diagnostic accuracy of cardiac peptides in detecting any left ventricular dysfunction (LVD) in patients referred from primary care with suspected HF before institution of medical therapy	CSS	4A+
Fuat et al. [222]	To test and compare the diagnostic accuracy and utility of B‐type natriuretic peptide (BNP) and N‐terminal B‐type natriuretic peptide (NT proBNP) in diagnosing heart failure due to left ventricular systolic dysfunction in patients with suspected heart failure referred by GPs to one‐stop diagnostic clinics	CSS	4A+