Pathogen	Recommended treatment
Highly resistant S. pneumoniae (>8 mg/dL)	Levofloxacin Moxifloxacin Vancomycin, teicoplanin Linezolid
MSSA	Flucloxacillin Cephalosporin II Clindamycin Levofloxacin Moxifloxacin
MRSA	Vancomycin, teicoplanin, ± rifampin Linezolid (Clindamycin if sensitive)
Ampicillin‐resistant H. influenzae	Aminopenicillin plus β‐lactamase inhibitor Levofloxacin Moxifloxacin
Mycoplasma pneumoniae	Doxycycline Macrolide Levofloxacin Moxifloxacin
Chlamydophila pneumoniae	Doxycycline Macrolide Levofloxacin Moxifloxacin
Legionella spp.	Levofloxacin Moxifloxacin (most data availabe for levofloxacin) Macrolide (azithromycin preferred) ± rifampicin
Coxiella burnetii	Doxycycline Levofloxacin Moxifloxacin
Acinetobacter baumanii	Third‐generation cephalosporin + aminoglycoside Ampicillin‐sulbactam

No experience in pneumonia for tigecycline.