Reference	Objective	Design	Evidence
Bruns et al. [285]	To study relation between day 3 and 7 CRP levels and inappropriate antibiotic therapy	PCS	3C+
Chalmers et al. [455]	To study CRP as severity predictor in CAP	PCS	3A+
Chen et al. [453]	To assess value of repeated PSI measurement as mortality predictor	PCS	3A+
Coelho et al. [456]	To study relationship between CRP and clinical course of CAP on the ICU	PCS	3A+
Hohenthal et al. [262]	To study relationship between daily CRP and complications in CAP	PCS	3A+
Menendez et al. [454]	Study of relationship between cytokines and treatment failure	PCS	3A+