| Reference | Objective | Design | Evidence |
|---|---|---|---|
| Wilson et al. [474] | A randomized open label study comparing oral gemifloxacin for 5 days with ceftriaxone i.m./cefuroxime orally 10 days in hospitalized patients with AECB | RCT | 2A+ |
| Martínez et al. [475] | A randomized trial comparing 5 days of levofloxacin (750 mg/24 h) with amoxicillin–clavulanic acid for 10 days | RCT | 2C+ |
| Dimopoulos et al. [476] | A meta‐analysis comparing first‐line with second‐line antibiotics in AECOPD | SR | 1A+ |
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