Reference | Objective | Design | Evidence |
Singh et al. [501] | Randomized controlled trials of any inhaled corticosteroid vs. a control treatment for COPD, with at least 24 weeks of follow‐up and reporting of pneumonia as an adverse event were included | MA | 1A+ |
Almirall et al. [502] | 1336 patients with confirmed CAP were matched to control subjects by age, sex and primary centre over 1 year. Multivariable analysis confirmed inhalation therapy (particularly containing steroids and using plastic pear‐spacers) as independent risk factors | CCS | 4B+ |
Ernst et al. [503] | To study the effect of inhaled corticosteroids on pneumonia hospitalization | CCS | 4B+ |
Drummond et al. [504] | To study the effect of inhaled corticosteroids on pneumonia mortality | MA | 1A+ |
Sin et al. [505] | Pooled patient data from seven clinical trials of inhaled budesonide for the risk of pneumonia | MA | 1A− |