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. 2011 Sep 26;17(Suppl 6):E1–E59. doi: 10.1111/j.1469-0691.2011.03672.x
Reference Objective Design Evidence
Singh et al. [501] Randomized controlled trials of any inhaled corticosteroid vs. a control treatment for COPD, with at least 24 weeks of follow‐up and reporting of pneumonia as an adverse event were included MA 1A+
Almirall et al. [502] 1336 patients with confirmed CAP were matched to control subjects by age, sex and primary centre over 1 year. Multivariable analysis confirmed inhalation therapy (particularly containing steroids and using plastic pear‐spacers) as independent risk factors CCS 4B+
Ernst et al. [503] To study the effect of inhaled corticosteroids on pneumonia hospitalization CCS 4B+
Drummond et al. [504] To study the effect of inhaled corticosteroids on pneumonia mortality MA 1A+
Sin et al. [505] Pooled patient data from seven clinical trials of inhaled budesonide for the risk of pneumonia MA 1A−