Table 1.
Susceptibilities of gonococcal strains to various antimicrobial agents and amino acid changes in GyrA and MtrR promotor
| Strain | MIC (μg/ml) |
Mutations in |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pen | AZI | TE | SPT | CRO | OFL | CIP | CIP+cccp70 | gyrA | mtrR promoter | |
| 76/WT | 4 | 0.25 | 2 | 16 | 0.03 | 0.5 | 0.12 | 0.03 | 91Tyr | A del |
| 76mu6 | 16 | 0.25 | 8 | 16 | 0.12 | 8 | 4 | 1 | 91Tyr | A del |
| 76mu10 | 16 | 0.25 | 8 | 8 | 0.25 | 8 | 16 | 4 | 91Tyr, 95Asn | A del |
| 92/WT | 0.25 | 0.12 | 0.12 | 16 | 0.008 | 0.06 | 0.004 | ND | – | – |
| 92mu6 | 0.5 | 1 | 2 | 8 | 0.015 | 4 | 2 | 0.03 | 95Asn | – |
| 92mu13 | 0.5 | 1 | 2 | 4 | 0.008 | 4 | 8 | 0.03 | 95Asn | – |
Abbreviation; PEN: Penicillin, AZI: Azithromycin, TE: Tetracycline, SPT: Spectinomycin, CRO: Ceftriaxone, OFL: Ofloxacin, CIP: Ciprofloxacin, CCCP: Carbonyl cyanide tri-chlorophenyl hydrazone