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| Antimicrobial concentration | Time initially detectable (h) | Time no longer detectable (h) | Peak concentration mcg/ml | Peak time (h) | AUC (mcgh/ml) | Percent initial amount detected |
|---|---|---|---|---|---|---|
| Linezolid 2.5% | – | – | <5 | – | – | – |
| Linezolid 7.5% | 1 ± 0 | 18 ± 9 | 64 ± 39 | 1±1 | 315 ± 144 | 17 ± 6 |
| Linezolid 15% | 1 ± 0 | 19 ± 4 | 65 ± 31 | 1±0 | 330 ± 64 | 18 ± 5 |
| Vancomycin 7.5% | 3±0 | 23 ± 1 | 19 ± 4 | 4±0 | 180 ± 8 | 11 ± 0 |
From Clin Orthop Rel Res 2002;403:49
