Table 2.

Outcome of 176 children with fever, neutropenia and a demonstrated respiratory viral infection, according to intervention

Characteristics	Type of intervention		Total	p
	Maintain antimicrobial	Antimicrobial withholding
	n = 92	n = 84
Days of antimicrobial therapy, median (IQR)	7 (7–9)	3 (3–4)	6 (3–7)	< 0.0001
Days of fever after admission, median (IQR)	2 (1–3)	1 (1–2)	1 (1–2)	0.44
Days of hospitalization, median (IQR)	6 (4–8)	6 (4–7)	6 (4–7)	0.65
Days of ANC <500/mm3, median (IQR)	5 (3–8)	4 (3–8)	5 (3–8)	0.23
Days of AMC <100/mm3, median (IQR)	3 (0–6)	2 (0–5)	3 (0–5)	0.46
Resolving uneventfully, n (%)	89 (97)	80 (95)	169 (96)	0.61
Demonstrated/probable invasive bacterial infection, n (%)	2 (2)	1 (1)	3 (2)	0.93
Re-instalment of antimicrobials, n (%)		4 (5)	4 (2)
Development of sepsis, n (%)	1 (1)	0	1 (1)
Admission to PICU, n (%)	1 (1)	0	1 (1)
Death, n (%)	0	0	0

Abbreviations: AMC, absolute monocyte count; ANC, absolute neutrophil count; IQR: Interquartile range; PICU, paediatric intensive care unit.