Table 3.
Viruses detected in LRTI patients and their matched controls
| Organism, n/total (%) | Patients with LRTI, |
Matched controls |
|||
|---|---|---|---|---|---|
| Day 1 (n = 3104)a | Days 28–35 (n = 2673)a | p-valueb | (n = 2063)a | p-valueb | |
| Rhinoviruses | 623 (20.1) | 113 (4.2) | <0.0001 | 72 (3.5) | <0.0001 |
| Influenza virus A/B | 307 (9.9) | 11 (0.4) | <0.0001 | 7 (0.3) | <0.0001 |
| Coronaviruses | 231 (7.4) | 71 (2.7) | <0.0001 | 29 (1.4) | <0.0001 |
| Respiratory syncytial virus | 144 (4.6) | 13 (0.5) | <0.0001 | 10 (0.5) | <0.0001 |
| Human metapneumovirus | 138 (4.4) | 7 (0.3) | <0.0001 | 3 (0.1) | <0.0001 |
| Parainfluenza viruses 1–4 | 81 (2.6) | 13 (0.5) | <0.0001 | 7 (0.3) | <0.0001 |
| Adenoviruses | 41 (1.3) | 42 (1.6) | 0.328 | 23 (1.1) | 0.831 |
| Polyomavirus | 69 (2.2) | 82 (3.1) | 0.017 | 52 (2.5) | 0.060 |
| Polyomavirus WU | 44 (1.4) | 54 (2.0) | 36 (1.7) | ||
| Polyomavirus KI | 27 (0.9) | 28 (1.0) | 17 (0.8) | ||
| Bocavirus | 18 (0.6) | 11 (0.4) | 0.433 | 16 (0.8) | 0.161 |
Abbreviations: CAP, community-acquired pneumonia; LRTI, lower respiratory tract infection.
a
Denominator varies per aetiological agent due to ‘not tested’ in max 0.6% on days 1 and 3.7% of samples on days 28–35 and missing data in controls.
b
The Generalized Estimating Equations took clustering of Day 1 and Days 28–35 samples within the same patients and clustering of Day 1 samples of patients and their matched controls into account.