Supplementary Fig. S7.

The electrostatic surfaces of two SVMP M domains. Gray spheres represent zinc atoms responsible for the catalytic reaction. The close view of the cleft active sites of two SVMPs and S1′ sites are enclosed with black squares. The hydrophobic regions (S1 and S2) in the K-like structure accommodating P1 and P2 residues of substrate are indicated with a dashed line. The negatively charged region enclosed in circles can accommodate Arg78 according to the docking model of K-like and the peptide Q⁷⁵AVRS derived from the linker domain of pro-TNFα at the right.