Fig. 5.

The inhibitory effect of atragin, K-like and peptides derived from the HVR in C domains, respectively, on cell migration. (A) Superposition of C domains from four P-III SVMP structures colored as Fig. 2A. The Cw domain structures are similar and rigid among SVMPs, whereas the Ch domains show larger variations, especially in the HVR (in the rectangle). The HVR of atragin is indicated in blue. Another notably variable region is at amino acids 535–555 (in the circle). The peptide residues, V⁵⁶⁰KCGRLFCKRRNSMI⁵⁷⁴, are indicated by arrows. (B) The inhibitory effect on cell NIH3T3 and CHOK1 migration with atragin and K-like, respectively. (C) The inhibitory effect on cell NIH3T3 migration with two peptides atragin-P and K-like-P derived from HVRs of atragin and K-like, respectively.