Fig. 6.

Implications for shedding models of ADAMs based on two SVMP structures from Naja atra. The shedding models of ADAMs are placed on the membrane (purple region). The shedding model (I) is based on the C-shaped MDC architecture, whereas the shedding models (II, III) are based on the I-shaped MDC architecture. The EGF-like domains are shown as brown octagons. The distance between the membrane and zinc ions (gray spheres) in the cleft active site is about 5 nm in the model (I). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)