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. 2020 Mar 31;12:2381–2391. doi: 10.2147/CMAR.S236565

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© 2020 Sun et al.

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Knockdown of B3GNT3 suppresses lung cancer development in vivo. (A) Lung cancer cells A549 transfected with negative control (sh-NC) or sh-B3GNT3 were implanted subcutaneously into nude mice and the tumor growth was monitored and measured at indicated time points. (B, C) Representative luciferase photographs and relative photon flux of nude mice and lung tumor tissues from sh-NC and sh-B3GNT3 groups at week 5. (D) Tumor weight in nude mice of sh-NC or sh-B3GNT3 group was analyzed. (E) Representative H&E staining and IHC staining of B3GNT3 and Ki-67 of tumor sections from sh-NC or sh-B3GNT3 group. Scale bar = 200 μm. (F) Quantification of relative IHC staining intensity of B3GNT3 and Ki-67 in tumor sections from sh-NC or sh-B3GNT3 group. **p < 0.01.