Table 2.

Log₁₀ reduction factors for virus inactivation procedures used in IVIG production

Inactivation step	Enveloped virus reduction (log10)
	HIV	BVDV	PRV
SD (TNBP-cholate) [63]	≥5.2	≥4.2	≥4.6
SD (TNBP-Triton X-100, Tween 80) [64]	>3.7	>4.9	>4.1
20 mM caprylate [40]	≥4.5	≥4.5	≥4.6
10 h @ 60 °C [65]	>5.4	>6.4	>3.6
pH 4-pepsin [66]	>6.1	>4.4	>5.3
pH 4.25, 21 d @ 25 °C [40]	>6.5	3.5	≥4.3

SD = solvent and detergent.