. 2006 Apr 3;35(1):35–42. doi: 10.1016/j.biologicals.2006.01.002

Table 4.

Elimination of hamster scrapie infectivity during manufacturing of IVIG (Carimune NF^®) [51]

Process (step in Fig. 1)	Mechanism	Log₁₀ reduction
Precipitate A to filtrate B (1)	p	3.5
IgG precipitate to IgG filtrate 1 (2)	p	4.5
IgG filtrate 1 to IgG Virusfiltrate (3)	n	4.4
Clarification (depth) filtration (5)	p	2.8
Step (2) and (5) combined	p	7.2

Overall reduction		15.2

Mechanism: p: partitioning; n: virusfiltration.