Table 2.
Details of correlations using Spearman’s ρ correlation coefficient between cytokines and acute phase proteins in broncho-alveolar lavage fluid, lung virus titres (VT), neutrophil (neutro) infiltration in BALF and clinical score (CS).
| IFN-α | IL-6 | IL-1 | TNF-α | IFN-γ | IL-18 | IL-12 | HG | CRP | LBP | VT | Neutro | CS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-α | 1 | 0.920a | 0.812a | 0.899a | 0.856a | −0.530 | 0.925a | 0.386 | 0.275 | 0.608 | 0.962a | 0.861a | 0.738a |
| IL-6 | – | 1 | 0.777a | 0.918a | 0.932a | −0.533 | 0.893a | 0.274 | 0.178 | 0.670a | 0.940a | 0.855a | 0.819a |
| IL-1 | – | – | 1 | 0.787a | 0.766a | −0.390 | 0.717a | −0.069 | −0.016 | 0.243 | 0.788a | 0.733a | 0.689a |
| TNF-α | – | – | – | 1 | 0.901a | −0.573 | 0.870a | 0.193 | 0.164 | 0.534 | 0.912a | 0.801a | 0.815a |
| IFN-γ | – | – | – | – | 1 | −0.486 | 0.814a | 0.119 | 0.137 | 0.561 | 0.884a | 0.799a | 0.717a |
| IL-18 | – | – | – | – | – | 1 | −0.603 | −0.332 | −0.591 | −0.506 | −0.549 | −0.541 | −0.565a |
| IL-12 | – | – | – | – | – | – | 1 | 0.355 | 0.430 | 0.766a | 0.889a | 0.920a | 0.843a |
| HG | – | – | – | – | – | – | – | 1 | 0.558 | 0.437 | 0.314 | 0.218 | 0.571 |
| CRP | – | – | – | – | – | – | – | – | 1 | 0.481 | 0.160 | 0.354 | 0.463 |
| LBP | – | – | – | – | – | – | – | – | – | 1 | 0.600 | 0.759a | 0.689a |
| VT | – | – | – | – | – | – | – | – | – | – | 1 | 0.860a | 0.691a |
| Neutro | – | – | – | – | – | – | – | – | – | – | – | 1 | 0.704a |
| CS | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
IFN, interferon; IL, interleukin; TNF, tumour necrosis factor; HG, haptoglobin; LPS, lipopolysaccharide; LBP, LPS-binding protein; CRP, C-reactive protein.
a
Correlation is significant at the 0.01 level.