Table 3.
Details of correlations using Spearman’s ρ correlation coefficient between cytokines and acute phase proteins in serum, lung virus titres (VT), neutrophil (neutro) infiltration in broncho-alveolar lavage fluid and clinical score (CS).
| IFN-α | IL-6 | IL-1 | TNF-α | IFN-γ | IL-18 | IL-12 | HG | CRP | LBP | VT | Neutro | CS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-α | 1 | 0.821a | NA | NA | 0.894a | −0.287 | NA | 0.444 | 0.524 | 0.258 | 0.892a | 0.823a | 0.744a |
| IL-6 | – | 1 | NA | NA | 0.914a | −0.504 | NA | 0.308 | 0.380 | 0.198 | 0.871a | 0.895a | 0.811a |
| IL-1 | – | – | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| TNF-α | – | – | – | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| IFN-γ | – | – | – | – | 1 | −0.408 | NA | 0.258 | 0.424 | 0.280 | 0.906a | 0.770a | 0.767a |
| IL-18 | – | – | – | – | – | 1 | NA | −0.221 | 0.000 | −0.022 | −0.188 | −0.388 | −0.456 |
| IL-12 | – | – | – | – | – | – | NA | NA | NA | NA | NA | NA | NA |
| HG | – | – | – | – | – | – | – | 1 | 0.637a | −0.203 | 0.339 | 0.412 | 0.429 |
| CRP | – | – | – | – | – | – | – | – | 1 | 0.136 | 0.476 | 0.357 | 0.629a |
| LBP | – | – | – | – | – | – | – | – | – | 1 | 0.270 | 0.271 | 0.251 |
| VT | – | – | – | – | – | – | – | – | – | – | 1 | 0.860a | 0.691a |
| Neutro | – | – | – | – | – | – | – | – | – | – | – | 1 | 0.704a |
| CS | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
NA, not applicable; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor; HG, haptoglobin; LPS, lipopolysaccharide; LBP, LPS-binding protein; CRP, C-reactive protein.
a
Correlation is significant at the 0.01 level.