Table 3.
Comparison of clinical features between 621 hospitalized children with or without LRTIs or PICU admission
| Characteristics | LRTI, n (%) |
Non-LRTI, n (%) |
p | PICU, n (%) |
Non-PICU, n (%) |
p |
|---|---|---|---|---|---|---|
| Case number | 75 | 546 | 20 | 601 | ||
| Genotypes | ||||||
| HAdV-2 | 3 (4.0) | 55 (10.1) | 0.09 | 2 (10.0) | 56 (9.3) | 0.918 |
| HAdV-3 | 40 (53.3) | 382 (69.9) | 0.004 | 8 (40.0) | 414 (68.9) | 0.006 |
| HAdV-7 | 32 (42.7) | 109 (19.9) | <0.001 | 10 (50.0) | 131 (21.8) | 0.003 |
| Fever | 74 (98.6) | 535 (98.0) | 0.757 | 19 (95.0) | 590 (98.2) | 0.311 |
| Fever>39°C | 72 (96.0) | 508 (93.0) | 0.331 | 18 (90.0) | 561 (93.5) | 0.536 |
| Duration (days) | 7.96±7.46 | 4.20±3.37 | <0.001 | 8.7±5.31 | 5.55±2.26 | <0.001 |
| >7 days | 36 (48.0) | 57 (10.4) | <0.001 | 11 (55) | 82 (13.6) | <0.001 |
| Peak or nadir leucocyte count, mean±SD | 12.99±7.46 | 12.68±5.47 | 0.673 | 15.72±8.13 | 12.59±5.58 | 0.004 |
| <5000/μL | 8 (10.6) | 16 (2.9) | <0.001 | 2 (10.0) | 22 (3.7) | 0.148 |
| >15 000/μL | 22 (29.3) | 141 (25.8) | 0.227 | 9 (45.0) | 154 (25.6) | 0.053 |
| Peak CRP, mean±SD (mg/L) | 85.05±38.97 | 70.37±52.8 | 0.033 | 109.57±86.44 | 70.76±52.03 | 0.021 |
| >100 mg/L | 28 (37.7) | 146 (26.8) | 0.055 | 8 (40.0) | 166 (27.6) | 0.225 |
| Underlying diseases | 6 (8) | 8 (1.5) | 0.003 | 6 (30) | 8 (1.3) | <0.001 |
| Neurology | 3 | 0 | 3 | 0 | ||
| Pulmonary | 0 | 1 | 0 | 1 | ||
| Gastrointestinal | 3 | 0 | 3 | 0 | ||
| Cardiovascular | 0 | 7 | 0 | 7 | ||
| Others | 1 | 6 | 1 | 6 | ||
| Antibiotic treatment | 72 (96.0) | 309 (56.6) | <0.001 | 20 (100) | 361 (60.1) | <0.001 |
| LOS (days) | 9.13±9.42 | 4.20±3.37 | <0.001 | 20.0±17.89 | 4.24±2.17 | <0.001 |
Abbreviations: CRP, C-reactive protein; HAdV-2, -3 and -7, human adenoviruses types 2, 3 and 7; LOS, length of hospital stay; LRTI, lower respiratory tract infection; PICU, paediatric intensive care unit.